Jinan Transon CNC Equipment Co., Ltd.
S I N C E 2 0 1 0
Latest products
Microfluidic what are some popular application field
by：Transon
2021-01-08
Popular applications
1. IVD( In vitro diagnostic)
microfluidic chip subversive advantages in some respects, IVD products will become the mainstream technology in vitro were tested.
1. 1 organ chip
organ chip is to point to in a microfluidic chip platform simulation organ function of a kind of science and technology, is the 2016 world of davos BBS selection & quot; Ten emerging technologies & quot; One of the. Its main goal is through the chip simulation environment of the organism, cells, tissue and organ culture, study and control in the process of cell culture in vitro biological behavior, so as to realize simulation of biological environment of organ transplantation and medicinal properties evaluation and so on. Organ chips to make a complex system, there are kidney, liver chip, chip islet chip, chip, and tumor blood sugar hubei chip product such as clinical application.
1. 2 liquid biopsy
in CTC to detect circulating tumor cells, for example, in the tumour stage test, dynamic test, curative effect evaluation, drug development and prognosis of detection is of great significance, is a kind of liquid biopsy could be used to replace biopsy new technology. Now, however, depends on the incidence of antibodies in the single CTC immune enrichment and technical methods cannot capture of different classification of CTC to conduct a comprehensive and hard to nondestructive release of CTC, unable to provide information about the depth of molecular pathology. Through the microfluidic technology, can obtain more can recognize different CTCS high affinity, high specificity of nucleic acid sequence, and by building a microfluidic chip array micro column, realize high capture and nondestructive release of CTC. The accuracy of this method in cancer diagnosis and medication guide, curative effect evaluation aspects have important application prospect.
2. Environmental and biochemical analysis
will move integrated valve integrated on a chip, build rotation analysis platform, through the rotary valve control channel between the links and disconnect to achieve control of the fluid. The method and enzyme-linked immune analysis combined with the chip, and build based on microfluidic chip color sensor, according to the intensity of the color signals, for quantitative analysis of contaminant concentration. Using this method to analyze the various environmental pollutants, and simple operation, high integration, has the good development potential.
3. Single-cell analysis
cells is the basis of existence and explore the life and health and disease often need on the basis of cell research. Due to the differences between cells and cells, cell group the results of the average of a group of cells, the individual differences tend to hide information. Microfluidic chip provides a new way of thinking for the research of cell biology function.
4. Nucleic acid analysis
the microfluidic chip technology used for PCR amplification and related inspection can simplify the operation procedures and improve efficiency. In this regard, based on microfluidic technology of micro droplet digital PCR ( ddH2O) Is a successful example. Digital PCR is a new kind of nucleic acid detection and quantitative methods, with the help of micro droplet or micro pit, through a single template molecule PCR amplification, which can realize is not dependent on the sample of accurate, absolute quantitative standard curve and reference. Digital PCR reaction is more sensitive, the results more reliable and more intuitive, especially suitable for trace or trace DNA tests and quantitative.
5. Drug screening
drug screening is the modern test in drug development process and obtain a step of certain physiological active compounds. Microfluidic chip technology because of the small sample consumption, high speed, high efficiency and solution system is close to the bio fluid composition characteristics, has become a very promising drugs and leading compounds of efficient screening tool.
this platform can be integrated microfluidic chip 256 or microarray, cell culture chamber change cell routine culture method, realizing the cell drug screening qualcomm. Chip micro-nano upgrade volume greatly reduced the reagent consumption, reduce the cost of drug screening; Microfluidic chip design of two dimensional structure or area can produce low shear stress, three dimensional microstructure formed in the substrate concentration gradient, and then an analysis of the toxicity of drugs; Microfluidic chip integration, synthesize drug separation enrichment, the experimental effect of cell culture, drug testing several steps such as integrated on a chip, realizes the automatic analysis of drug screening.
in the
microfluidic technology has developed rapidly in recent years, the chip integrated unit parts more and more, and integration is becoming more and more large scale, at the same time, microfluidic chip can be a large number of samples of parallel processing, high flux, analysis the characteristics of low speed and material consumptions, small pollution, make it as material science, chemistry, life science, biology, medicine and other fields and application provides the basis of a strong platform.
although already had so many exciting and compelling development, but we still face challenges in the field of microfluidics, mainly embodied in the theoretical research concept and transformation between the practical technology to solve the problem of the real world. Therefore, in the future, we still should focus on basic research, promote the development of the field, but also should pay attention to the use of microfluidics technology, especially in the field of high flux. Believe that soon, microfluidic products will enter the market in succession, for human life and health development and ecological environment protection play an important role.
1. IVD( In vitro diagnostic)
microfluidic chip subversive advantages in some respects, IVD products will become the mainstream technology in vitro were tested.
1. 1 organ chip
organ chip is to point to in a microfluidic chip platform simulation organ function of a kind of science and technology, is the 2016 world of davos BBS selection & quot; Ten emerging technologies & quot; One of the. Its main goal is through the chip simulation environment of the organism, cells, tissue and organ culture, study and control in the process of cell culture in vitro biological behavior, so as to realize simulation of biological environment of organ transplantation and medicinal properties evaluation and so on. Organ chips to make a complex system, there are kidney, liver chip, chip islet chip, chip, and tumor blood sugar hubei chip product such as clinical application.
1. 2 liquid biopsy
in CTC to detect circulating tumor cells, for example, in the tumour stage test, dynamic test, curative effect evaluation, drug development and prognosis of detection is of great significance, is a kind of liquid biopsy could be used to replace biopsy new technology. Now, however, depends on the incidence of antibodies in the single CTC immune enrichment and technical methods cannot capture of different classification of CTC to conduct a comprehensive and hard to nondestructive release of CTC, unable to provide information about the depth of molecular pathology. Through the microfluidic technology, can obtain more can recognize different CTCS high affinity, high specificity of nucleic acid sequence, and by building a microfluidic chip array micro column, realize high capture and nondestructive release of CTC. The accuracy of this method in cancer diagnosis and medication guide, curative effect evaluation aspects have important application prospect.
2. Environmental and biochemical analysis
will move integrated valve integrated on a chip, build rotation analysis platform, through the rotary valve control channel between the links and disconnect to achieve control of the fluid. The method and enzyme-linked immune analysis combined with the chip, and build based on microfluidic chip color sensor, according to the intensity of the color signals, for quantitative analysis of contaminant concentration. Using this method to analyze the various environmental pollutants, and simple operation, high integration, has the good development potential.
3. Single-cell analysis
cells is the basis of existence and explore the life and health and disease often need on the basis of cell research. Due to the differences between cells and cells, cell group the results of the average of a group of cells, the individual differences tend to hide information. Microfluidic chip provides a new way of thinking for the research of cell biology function.
4. Nucleic acid analysis
the microfluidic chip technology used for PCR amplification and related inspection can simplify the operation procedures and improve efficiency. In this regard, based on microfluidic technology of micro droplet digital PCR ( ddH2O) Is a successful example. Digital PCR is a new kind of nucleic acid detection and quantitative methods, with the help of micro droplet or micro pit, through a single template molecule PCR amplification, which can realize is not dependent on the sample of accurate, absolute quantitative standard curve and reference. Digital PCR reaction is more sensitive, the results more reliable and more intuitive, especially suitable for trace or trace DNA tests and quantitative.
5. Drug screening
drug screening is the modern test in drug development process and obtain a step of certain physiological active compounds. Microfluidic chip technology because of the small sample consumption, high speed, high efficiency and solution system is close to the bio fluid composition characteristics, has become a very promising drugs and leading compounds of efficient screening tool.
this platform can be integrated microfluidic chip 256 or microarray, cell culture chamber change cell routine culture method, realizing the cell drug screening qualcomm. Chip micro-nano upgrade volume greatly reduced the reagent consumption, reduce the cost of drug screening; Microfluidic chip design of two dimensional structure or area can produce low shear stress, three dimensional microstructure formed in the substrate concentration gradient, and then an analysis of the toxicity of drugs; Microfluidic chip integration, synthesize drug separation enrichment, the experimental effect of cell culture, drug testing several steps such as integrated on a chip, realizes the automatic analysis of drug screening.
in the
microfluidic technology has developed rapidly in recent years, the chip integrated unit parts more and more, and integration is becoming more and more large scale, at the same time, microfluidic chip can be a large number of samples of parallel processing, high flux, analysis the characteristics of low speed and material consumptions, small pollution, make it as material science, chemistry, life science, biology, medicine and other fields and application provides the basis of a strong platform.
although already had so many exciting and compelling development, but we still face challenges in the field of microfluidics, mainly embodied in the theoretical research concept and transformation between the practical technology to solve the problem of the real world. Therefore, in the future, we still should focus on basic research, promote the development of the field, but also should pay attention to the use of microfluidics technology, especially in the field of high flux. Believe that soon, microfluidic products will enter the market in succession, for human life and health development and ecological environment protection play an important role.
Custom message
