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Microfluidic technology can be used in those areas
by：Transon
2021-01-11
The application of microfluidic chip technology
microfluidic technology available so far has a history of nearly 30 years, but its development is swift and violent, known as the next generation of medical diagnosis & quot; Disruptive technology & quot; 。
by using microfluidic chip research have been continuously, has a research on breast cancer cell metastasis related has used the technology. From researchers at the university of Michigan in Ann arbor, take advantage of new development of high throughput microfluidic chip, one of the important features of metastatic breast cancer cells were found & ndash; Consuming between mesenchymal stem cells ( MSC) 。 Cancer cells by devouring MSC according to the study, enhance their aggressive, let the cancer spread rapidly development. Research suggests that to prevent breast cancer cell lines of consuming behavior, is expected to become the new direction for containment of breast cancer metastasis, and related genes and molecules is breast cancer diagnosis and treatment of potential target, it will be bring new hope for many patients. In addition, we have about the application of microfluidic chip as a simple introduction.
cell sorting
through different separation principle, microfluidic chip can realize the separation of different cells. In circulating tumor cells ( ctc) As an example, the cell is mainly from tumor tissue spontaneously fall off in the peripheral blood, the transfer has an important influence on malignant tumor spread, has gradually been considered a sign of tumor distant metastasis. Trace amounts in the peripheral blood of CTCs with specificity and sensitivity for separation, enrichment and detection, is not only beneficial to tumor recurrence of early diagnosis and curative effect evaluation and monitoring, can also for subsequent downstream of CTCs identification and single cell genome and transcriptome sequencing provides good foundation, to provide new strategies for cancer targeted therapy, personalized medicine and other fields has important significance in clinic.
microfluidic techniques can be integrated under micro-metre scale physical, chemical and biological methods, implementation of trace CTCs separation enrichment of high flux, high efficiency and low cost, the technology is developing rapidly and has been widely research and application. Fluxion Biosciences microfluidic platform used for the development of the new IsoFlux use microfluidic channels to ensure the magnetic particles marks of CTCs reliably fully exposed in the dense and uniform magnetic field intensity, in order to realize efficient cell enrichment recycling.
drug screening
drug screening is the modern test in drug development process and obtain a step of certain physiological active compounds. Microfluidic chip technology because of the small sample consumption, high speed, high efficiency and solution system is close to the bio fluid composition characteristics, has become a very promising drugs and leading compounds of efficient screening tool.
256 microfluidic chip can be integrated or microarray, cell culture chamber change cell routine culture method, realizing the cell drug screening qualcomm. Chip micro-nano upgrade volume greatly reduced the reagent consumption, reduce the cost of drug screening; Microfluidic chip design of two dimensional structure or area can produce low shear stress, three dimensional microstructure formed in the substrate concentration gradient, and then an analysis of the toxicity of drugs; Microfluidic chip integration, synthesize drug separation enrichment, the experimental effect of cell culture, drug testing several steps such as integrated on a chip, realizes the automatic analysis of drug screening.
integrated chip and organs bionic
in vitro model of biological tissue, organ is to reveal the indispensable tool of human physiology and pathology. And organ model based on microfluidic chip by cell culture or assembled in a specific manner to the microfluidic chip, according to the structure of organs in an organism for in vitro reconstruction, in order to study specific physiological functions of organs and constructs a model of specific diseases in vitro. This technique for the drug toxicity and efficacy of prediction are more potential than conventional model in vitro, it can provide for a more detailed understanding of the mechanism of action of tissue and organ level, can be applied to drug absorption, distribution, metabolism and excretion of prediction and research of drug toxicity.
in microfluidic technology in the research and application in the nervous system diseases, for example, in the past research, animal models are usually used in the simulation of the structure of the brain and its related diseases, but this method is expensive, low efficiency, the complex and time-consuming, severely limits the development of nerve disease research. In recent years, the use of microfluidic chip technology has been able to in vitro simulation of the central nervous system (well CNS) , disease model is set up, and then let us to neurological diseases, such as alzheimer's disease, Parkinson's disease research have a deeper understanding.
microfluidic chip to make the best equipment: HZZ - endeavour V3000( 我。 LASER3000/4000) Details please contact us.
microfluidic technology available so far has a history of nearly 30 years, but its development is swift and violent, known as the next generation of medical diagnosis & quot; Disruptive technology & quot; 。
by using microfluidic chip research have been continuously, has a research on breast cancer cell metastasis related has used the technology. From researchers at the university of Michigan in Ann arbor, take advantage of new development of high throughput microfluidic chip, one of the important features of metastatic breast cancer cells were found & ndash; Consuming between mesenchymal stem cells ( MSC) 。 Cancer cells by devouring MSC according to the study, enhance their aggressive, let the cancer spread rapidly development. Research suggests that to prevent breast cancer cell lines of consuming behavior, is expected to become the new direction for containment of breast cancer metastasis, and related genes and molecules is breast cancer diagnosis and treatment of potential target, it will be bring new hope for many patients. In addition, we have about the application of microfluidic chip as a simple introduction.
cell sorting
through different separation principle, microfluidic chip can realize the separation of different cells. In circulating tumor cells ( ctc) As an example, the cell is mainly from tumor tissue spontaneously fall off in the peripheral blood, the transfer has an important influence on malignant tumor spread, has gradually been considered a sign of tumor distant metastasis. Trace amounts in the peripheral blood of CTCs with specificity and sensitivity for separation, enrichment and detection, is not only beneficial to tumor recurrence of early diagnosis and curative effect evaluation and monitoring, can also for subsequent downstream of CTCs identification and single cell genome and transcriptome sequencing provides good foundation, to provide new strategies for cancer targeted therapy, personalized medicine and other fields has important significance in clinic.
microfluidic techniques can be integrated under micro-metre scale physical, chemical and biological methods, implementation of trace CTCs separation enrichment of high flux, high efficiency and low cost, the technology is developing rapidly and has been widely research and application. Fluxion Biosciences microfluidic platform used for the development of the new IsoFlux use microfluidic channels to ensure the magnetic particles marks of CTCs reliably fully exposed in the dense and uniform magnetic field intensity, in order to realize efficient cell enrichment recycling.
drug screening
drug screening is the modern test in drug development process and obtain a step of certain physiological active compounds. Microfluidic chip technology because of the small sample consumption, high speed, high efficiency and solution system is close to the bio fluid composition characteristics, has become a very promising drugs and leading compounds of efficient screening tool.
256 microfluidic chip can be integrated or microarray, cell culture chamber change cell routine culture method, realizing the cell drug screening qualcomm. Chip micro-nano upgrade volume greatly reduced the reagent consumption, reduce the cost of drug screening; Microfluidic chip design of two dimensional structure or area can produce low shear stress, three dimensional microstructure formed in the substrate concentration gradient, and then an analysis of the toxicity of drugs; Microfluidic chip integration, synthesize drug separation enrichment, the experimental effect of cell culture, drug testing several steps such as integrated on a chip, realizes the automatic analysis of drug screening.
integrated chip and organs bionic
in vitro model of biological tissue, organ is to reveal the indispensable tool of human physiology and pathology. And organ model based on microfluidic chip by cell culture or assembled in a specific manner to the microfluidic chip, according to the structure of organs in an organism for in vitro reconstruction, in order to study specific physiological functions of organs and constructs a model of specific diseases in vitro. This technique for the drug toxicity and efficacy of prediction are more potential than conventional model in vitro, it can provide for a more detailed understanding of the mechanism of action of tissue and organ level, can be applied to drug absorption, distribution, metabolism and excretion of prediction and research of drug toxicity.
in microfluidic technology in the research and application in the nervous system diseases, for example, in the past research, animal models are usually used in the simulation of the structure of the brain and its related diseases, but this method is expensive, low efficiency, the complex and time-consuming, severely limits the development of nerve disease research. In recent years, the use of microfluidic chip technology has been able to in vitro simulation of the central nervous system (well CNS) , disease model is set up, and then let us to neurological diseases, such as alzheimer's disease, Parkinson's disease research have a deeper understanding.
microfluidic chip to make the best equipment: HZZ - endeavour V3000( 我。 LASER3000/4000) Details please contact us.
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