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Using high precision laser cutting production through porous microcarrier microfluidic building height
by：Transon
2021-01-08
Professor Chen Aizheng team in huaqiao university institute of chemical using microfluidic technology building highly porous microcarrier for skeletal muscle cells through gain important research progress in minimally invasive in situ delivery, relevant research results to & quot;
高度多孔微载体微创原位骨骼肌细胞交付”
Topic on June 21, officially published in the international journal 'Small' authority, and was selected as the cover story,
封面)
。
'Small' is a subsidiary of German Wiley press top journals, belong to the Chinese Academy of Engineering area, the current impact factor of 10.
856.
Chen Aizheng professor team using microfluidic technology based on poly (lactic acid - was successfully achieved Glycolic acid copolymer ( poly( 乳酸- 合作 乙醇酸) , PLGA) The height of the well versed in porous microcarrier ( 高度开放的多孔微球,HOPMs) And skeletal muscle cells as the model, evaluated its cells proliferation and deliver results. Through the microfluidic technology preparation of porous PLGA microspheres particle size is 280 ~ 370 & mu; M, with open and connectivity of pores, aperture of 10 ~ 80 & mu; m。 At the same time, the carrier has good degradability, cell adhesion and proliferation in performance. In addition, the research work by using real-time quantitative polymerase chain reaction, immunofluorescence staining, histological staining, and other methods to analyze cells on the microcarrier cell behavior, to verify that the cells in vitro to construct a single spherical micro organization. Finally, these load cells HOPMs after being injected into experimental animals, delivery of myoblast in ideal site and rapid appreciation. The research results show that this preparation based on microfluidic technology through porous microcarrier in tissue repair and regeneration medicine has potential application prospects.
the above research work by the overseas Chinese university institute of chemical industry institute of biomaterials and tissue engineering at harvard medical school professor Chen Aizheng group, Yu Shrike professor Zhang, team cooperation, fujian medical university, Dr Yang Dayun Dr Zhu armoured in zhongshan hospital of fudan university. Joint research by the national natural science fund channel key projects 'can be injected compound biological scaffold mediated vascularized muscle tissue in situ regeneration of research ( U1605225) And biological materials in fujian province science and technology innovation team project funding.
Chen Aizheng professor team using microfluidic technology based on poly (lactic acid - was successfully achieved Glycolic acid copolymer ( poly( 乳酸- 合作 乙醇酸) , PLGA) The height of the well versed in porous microcarrier ( 高度开放的多孔微球,HOPMs) And skeletal muscle cells as the model, evaluated its cells proliferation and deliver results. Through the microfluidic technology preparation of porous PLGA microspheres particle size is 280 ~ 370 & mu; M, with open and connectivity of pores, aperture of 10 ~ 80 & mu; m。 At the same time, the carrier has good degradability, cell adhesion and proliferation in performance. In addition, the research work by using real-time quantitative polymerase chain reaction, immunofluorescence staining, histological staining, and other methods to analyze cells on the microcarrier cell behavior, to verify that the cells in vitro to construct a single spherical micro organization. Finally, these load cells HOPMs after being injected into experimental animals, delivery of myoblast in ideal site and rapid appreciation. The research results show that this preparation based on microfluidic technology through porous microcarrier in tissue repair and regeneration medicine has potential application prospects.
the above research work by the overseas Chinese university institute of chemical industry institute of biomaterials and tissue engineering at harvard medical school professor Chen Aizheng group, Yu Shrike professor Zhang, team cooperation, fujian medical university, Dr Yang Dayun Dr Zhu armoured in zhongshan hospital of fudan university. Joint research by the national natural science fund channel key projects 'can be injected compound biological scaffold mediated vascularized muscle tissue in situ regeneration of research ( U1605225) And biological materials in fujian province science and technology innovation team project funding.
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