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Microfluidic technology development and the use of microfluidic laser equipment
by：Transon
2021-01-08
10 - to be able to control
9 ~ 10 -
18 l trace amounts of liquid, it as how precise bearing of the chip is! ! !
A chip from processing to the final molding experience which steps?
What is the technical problems every step?
With small make up together and see it.
1. Microfluidic chip processing
this step should be considered, cost structure, pipe size, problems such as being able to mass production. Now technology are:
photolithography and etching technology, hot pressing method, molding, injection molding, journalist on ( Collection of lithography, electroforming and mold casting) , laser ablation method, soft lithography 2. Microfluidic chip sealing issue to consider in this step are: high temperature performance degradation, the normal temperature aging, the option seal or face seal, the question of whether or not to pipeline and production. Current technology mainly include:
Plasma ionization/bonding, lamination method, ultrasonic welding, laser welding, thermal bonding.
3. Microfluidic fluid drive
this step needs to consider the main pump, valve, including is active or passive choice, and whether it is stable and reliable, etc. On the other hand to consider fluid width, depth, and the size of the chamber, the quantitative analysis and qualitative analysis, etc. Current driven methods mainly include:
optical, electric, magnetic field, extrusion vesicles, diaphragm to vibrate, pump, centrifugal force and shear force.
4. Design of aerosol pollution
this step needs to consider to choose what kind of material or method reduce the aerosol pollution as much as possible. Now can take method is as follows:
sealed reaction system after amplification, whole sealing system, silicone oil seal, after joining samples, seal sample button hole, the structure, sealing by hand.
5. Instrument signal detection
the microfluidic droplet signal acquisition, here comes to the main techniques are:
visual read, read and amplification curve electrical signals.
6. Supporting software system
of course, light has a good microfluidic system chip is not enough, also need a simple and practical software system, it can greatly improve the user experience.
1. Microfluidic chip processing
this step should be considered, cost structure, pipe size, problems such as being able to mass production. Now technology are:
photolithography and etching technology, hot pressing method, molding, injection molding, journalist on ( Collection of lithography, electroforming and mold casting) , laser ablation method, soft lithography 2. Microfluidic chip sealing issue to consider in this step are: high temperature performance degradation, the normal temperature aging, the option seal or face seal, the question of whether or not to pipeline and production. Current technology mainly include:
Plasma ionization/bonding, lamination method, ultrasonic welding, laser welding, thermal bonding.
3. Microfluidic fluid drive
this step needs to consider the main pump, valve, including is active or passive choice, and whether it is stable and reliable, etc. On the other hand to consider fluid width, depth, and the size of the chamber, the quantitative analysis and qualitative analysis, etc. Current driven methods mainly include:
optical, electric, magnetic field, extrusion vesicles, diaphragm to vibrate, pump, centrifugal force and shear force.
4. Design of aerosol pollution
this step needs to consider to choose what kind of material or method reduce the aerosol pollution as much as possible. Now can take method is as follows:
sealed reaction system after amplification, whole sealing system, silicone oil seal, after joining samples, seal sample button hole, the structure, sealing by hand.
5. Instrument signal detection
the microfluidic droplet signal acquisition, here comes to the main techniques are:
visual read, read and amplification curve electrical signals.
6. Supporting software system
of course, light has a good microfluidic system chip is not enough, also need a simple and practical software system, it can greatly improve the user experience.
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