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Microfluidic chip detection technology including those paper
by：Transon
2021-01-08
Microfluidic (
Microfluidics)
Is a micron scale operation, the control technology of the fluid.
Microfluidic chip is a platform of microfluidic technology.
Through the analysis of the integration, miniaturization of instrument, but the analysis in the laboratory instruments, functional integration to a few square centimeters of chip.
Traditional microfluidic chip mainly material such as glass, silicon, high polymer as the basement, in microchannel, for network, micro pump, micro valve, micro electrode, micro reactor, the function such as detecting element IC like integrated circuit on a microchip.
paper-based microfluidic chip is & quot; Microfluidic paper analysis device & quot; ( 微流控纸- - - - - - 基于分析设备,μ 垫) Concept, through a variety of fine processing technology, fluid channel network built on the filter paper and related analysis, establish & quot; Paper miniature laboratory & quot; ( 实验室, 在- - - - - - 纸) 。 μ PADs will filter tap cheaply, good biocompatibility, and combining the traditional advantages of microfluidic chip, as it has caused wide attention. Paper-based microfluidic chip is particularly suitable for making & quot; After using disposable & quot; Analysis of the disposable sensor, has great application potential.
paper chip processing technology, in addition to the traditional microelectronic processing technology such as lithography, include paper conventional processing technology, such as printing, etc. Filter paper is rich in processing methods, combined with the technical requirements of the microfluidic chip, has formed a lot of difference between traditional unique technology of microfluidic chip processing means.
paper chip to realize the flow control and analysis of detection, the premise of is formed in the filter paper substrate is hydrophilic/hydrophobic channel network. Substrate processing technology from the combination of hydrophobic material and filter paper on the way, can be divided into physical adsorption and chemical combination; From the distribution of the hydrophobic material and the processing method, can be divided into lithography, plasma processing, printing, drawing, laser etching; Can also according to the processing of filter paper itself, can be divided into cutting, stacking and carving, paste and other technology. In the process of chip of paper, often need different processing techniques on the same paper base combining with processing. Chips, especially the three-dimensional paper pattern in the finished surface hydrophobic area, also need to be more pieces of paper cutting matrix, superposition, punching, paste, to form a three-dimensional scale of microfluidic channel.
paper microfluidic chip detection technology including colorimetric method, chemiluminescence method, fluorescence detection, electrochemiluminescence method, electrochemical method and surface enhanced Raman spectra, etc. Colorimetric analysis method to the chromogenic reaction between the analyte and substrate as the foundation, by comparing or measuring non-ferrous products change color or color intensity to the qualitative or quantitative detection of component under test. Chemiluminescence method is based on the reaction that at some point in the process of chemical luminescence intensity of quantitatively by using the analysis method of analyte when in contact with the detection area, have obvious luminous effect.
fluorescence analysis method is the use of fluorescent material by the excitation light emitted fluorescence on the qualitative or quantitative analysis method, the paper base of the whitening agent can cause a certain interference, to detect the fluorescence analysis itself still has a high applicability. Paper-based microfluidic chip fluorescence detection is usually combined with biological affinity adsorption.
the electrochemical luminescence is also called the ec chemiluminescence, the electrochemical luminescence method is adopted for analyte detection of microfluidic chip, the detection area need to set up a system of electrodes, usually use silk screen printing or electron beam evaporation, such as photolithography technology to produce three electrode system, and load chemiluminescence reagent, by applying a voltage, and the object under test light-emitting electrochemical luminescence reaction of reagent, light, signal can be obtained by the signal strength concentration in the object under test. Electrochemical method was also in the paper build a three electrode system on the base, using voltammetry and other specific detection methods to detect the contents of the object under test in the sample.
electrochemical detection is based on the sensor was chemical signals of the component under test can be converted to electrical signals for measurement method, compared with optics detection technology, the method of background interference smaller, higher sensitivity. Surface enhanced Raman scattering ( SERS) Refers to the adsorption on the metal surface or colloidal metal particles on the Raman signal amplification phenomenon of the sample. Filter paper for its micron grade roughness and porous fiber structure, as a load of metal nanoparticles basement, showed great superiority.
paper-based microfluidic chip is & quot; Microfluidic paper analysis device & quot; ( 微流控纸- - - - - - 基于分析设备,μ 垫) Concept, through a variety of fine processing technology, fluid channel network built on the filter paper and related analysis, establish & quot; Paper miniature laboratory & quot; ( 实验室, 在- - - - - - 纸) 。 μ PADs will filter tap cheaply, good biocompatibility, and combining the traditional advantages of microfluidic chip, as it has caused wide attention. Paper-based microfluidic chip is particularly suitable for making & quot; After using disposable & quot; Analysis of the disposable sensor, has great application potential.
paper chip processing technology, in addition to the traditional microelectronic processing technology such as lithography, include paper conventional processing technology, such as printing, etc. Filter paper is rich in processing methods, combined with the technical requirements of the microfluidic chip, has formed a lot of difference between traditional unique technology of microfluidic chip processing means.
paper chip to realize the flow control and analysis of detection, the premise of is formed in the filter paper substrate is hydrophilic/hydrophobic channel network. Substrate processing technology from the combination of hydrophobic material and filter paper on the way, can be divided into physical adsorption and chemical combination; From the distribution of the hydrophobic material and the processing method, can be divided into lithography, plasma processing, printing, drawing, laser etching; Can also according to the processing of filter paper itself, can be divided into cutting, stacking and carving, paste and other technology. In the process of chip of paper, often need different processing techniques on the same paper base combining with processing. Chips, especially the three-dimensional paper pattern in the finished surface hydrophobic area, also need to be more pieces of paper cutting matrix, superposition, punching, paste, to form a three-dimensional scale of microfluidic channel.
paper microfluidic chip detection technology including colorimetric method, chemiluminescence method, fluorescence detection, electrochemiluminescence method, electrochemical method and surface enhanced Raman spectra, etc. Colorimetric analysis method to the chromogenic reaction between the analyte and substrate as the foundation, by comparing or measuring non-ferrous products change color or color intensity to the qualitative or quantitative detection of component under test. Chemiluminescence method is based on the reaction that at some point in the process of chemical luminescence intensity of quantitatively by using the analysis method of analyte when in contact with the detection area, have obvious luminous effect.
fluorescence analysis method is the use of fluorescent material by the excitation light emitted fluorescence on the qualitative or quantitative analysis method, the paper base of the whitening agent can cause a certain interference, to detect the fluorescence analysis itself still has a high applicability. Paper-based microfluidic chip fluorescence detection is usually combined with biological affinity adsorption.
the electrochemical luminescence is also called the ec chemiluminescence, the electrochemical luminescence method is adopted for analyte detection of microfluidic chip, the detection area need to set up a system of electrodes, usually use silk screen printing or electron beam evaporation, such as photolithography technology to produce three electrode system, and load chemiluminescence reagent, by applying a voltage, and the object under test light-emitting electrochemical luminescence reaction of reagent, light, signal can be obtained by the signal strength concentration in the object under test. Electrochemical method was also in the paper build a three electrode system on the base, using voltammetry and other specific detection methods to detect the contents of the object under test in the sample.
electrochemical detection is based on the sensor was chemical signals of the component under test can be converted to electrical signals for measurement method, compared with optics detection technology, the method of background interference smaller, higher sensitivity. Surface enhanced Raman scattering ( SERS) Refers to the adsorption on the metal surface or colloidal metal particles on the Raman signal amplification phenomenon of the sample. Filter paper for its micron grade roughness and porous fiber structure, as a load of metal nanoparticles basement, showed great superiority.
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